Q: What is Pharmacogenetic Testing?
Pharmacogenetic testing, also called DNA Drug Sensitivity Testing, is the testing of certain genes to determine how individuals are going to react to specific medications. This greatly decreases the need for trial and error” dosing and can reduce the risk of Adverse Drug Reactions (ADRs) substantially.
Pharmacogenetics testing is a new tool in medicine. It’s just being introduced to many physicians, hospitals and clinics. Pharmacogenetics is a science that holds enormous promise, and will doubtless reduce medical costs and increase the effectiveness of many drugs in the future.
Q: What is the impact of Adverse Drug Reactions?
View our Adverse Drug Events page for a detailed answer on the impact adverse drug reactions.
Q: How well established is the science?
The science of pharmacogenetics is both well established and rapidly changing. That specific genes influence how individual react to medications is not in doubt. The genes have, in most cases, been identified, and variations in those genes tracked. The effect those variations have on specific medications, however, is sometimes less well established. For some drugs the effects are well documented and indicate specific changes in dosages. For others, therapeutic changes are not as well documented.
View our Resources page for additional resources on pharmacogenetic testing.
View our list of drugs that have been fully researched.
Q: What drugs does pharmacogenetic testing apply to?
The effect genetic variations have on specific medications is well documented for some drugs, and not well documented for others. In general, drugs with a very narrow effective dosing range have been researched, while drugs with a wide effective range have not.
Porite Labs currently offers DNA Drug Sensitivity Testing that test CYP2D6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, NAT2, and CYP1A2 functionality. The downloadable drug list has many commonly prescribed drugs that are metabolized through these pathways in the Cytochrome P-450 system.
The FDA has updated the label of more than 30 drugs to include pharmacogenetic information.
The DNA decides how the patient's genomes are working, and whether they're a rapid or a poor metabolizer of certain medication. The testing is done at Molecular Testing Labs.
“It’s your DNA. That does not change. How you process medication now is how you will process medication 20 years from now. So one test can determine a lot.
Porite Labs has the most innovative and advanced Testing available.